(plant-based diet[tiab] OR vegan diet[tiab] OR vegans[tiab]) AND

“The WFPB induced a clinically significant reduction in LDL-C relative to the SAD (-17.9%, 95% CI: -21.7%, -14.3%; P < 0.0001)”

study authors

A randomized, fully controlled crossover feeding trial with a statistically robust result; funded by the Canadian Institutes of Health Research, though one author discloses unrelated dairy-industry consulting.

In the brief: Whole-Food, Plant-Based Diet Cuts LDL Cholesterol 17.9% in Genetic High-Cholesterol Trial → (plant-based diet[tiab] OR vegan diet[tiab] OR vegans[tiab]) AND →

“Vegetarian diets compared to non-vegetarian diets are associated with reduced risk of total cancer and seven specific cancer types, while vegan diets are associated with reduced risk of total and breast cancer.”

study authors

A peer-reviewed meta-analysis of prospective studies whose authors grade the vegan-specific findings only "limited-suggestive" by WCRF criteria, more cautious than the "probable" rating given the stronger vegetarian associations.

In the brief: Meta-analysis finds vegetarian and vegan diets cut cancer risk in seven types → (plant-based diet[tiab] OR vegan diet[tiab] OR vegans[tiab]) AND →

“The WFPB induced a clinically significant reduction in LDL-C relative to the SAD (-17.9%, 95% CI: -21.7%, -14.3%; P < 0.0001)”

study authors

A randomized, fully controlled crossover feeding trial with genetically confirmed patients, though only 4 weeks per diet arm; one co-author discloses unrelated consulting fees from the Dairy Farmers of Canada.

In the brief: Whole-food plant-based diet cuts LDL cholesterol 17.9% in genetic cholesterol trial → (plant-based diet[tiab] OR vegan diet[tiab] OR vegans[tiab]) AND →

“Vegetarian diets compared to non-vegetarian diets are associated with reduced risk of total cancer and seven specific cancer types, while vegan diets are associated with reduced risk of total and breast cancer”

study authors

Built from 17 publications of observational cohort and case-control data; the authors themselves rated the vegan-diet evidence "limited-suggestive," not proven.

In the brief: Meta-analysis finds vegan diets lower total cancer risk by 23 percent → (plant-based diet[tiab] OR vegan diet[tiab] OR vegans[tiab]) AND →

“supports its re-establishment as a cornerstone in clinical guidelines”

study authors

A fully controlled, randomized crossover trial published in Nature Communications, though small (n=50) and short (4 weeks per diet).

In the brief: Whole-food plant-based diet cut LDL cholesterol 17.9% in genetic high-cholesterol trial → (plant-based diet[tiab] OR vegan diet[tiab] OR vegans[tiab]) AND →

“a plant-based meat supplemented diet led to significantly lower TMAO levels, suggesting that replacing red-meat with a plant-based diet may lead to a more favourable metabolic risk profile.”

study authors

A crossover trial of 41 people, six days per arm, real biomarkers but too small and short to call the metabolic picture settled, and weight and a heart-stress marker (NTproBNP) both ticked up on the plant-based arm.

In the brief: Trial finds plant-based meat cuts a heart-risk marker versus red meat → (plant-based diet[tiab] OR vegan diet[tiab] OR vegans[tiab]) AND →

“The healthful plant-based diet was associated with lower risk of dementia, whereas the unhealthful plant-based diet was linked to higher risk.”

study authors

Two cohort-based meta-analyses agree in direction, but heterogeneity between studies is high, and both call for randomized trials to prove cause.

In the brief: Diet quality splits plant-based eaters' dementia risk in two new meta-analyses → (plant-based diet[tiab] OR vegan diet[tiab] OR vegans[tiab]) AND →

“Vegetarian diets compared to non-vegetarian diets are associated with reduced risk of total cancer and seven specific cancer types, while vegan diets are associated with reduced risk of total and breast cancer.”

study authors

Two systematic reviews of prospective cohort and case-control studies, sound design, but observational, so this shows association, not proof of cause.

In the brief: Meta-analysis finds vegan diets cut total cancer risk by 23 percent → (plant-based diet[tiab] OR vegan diet[tiab] OR vegans[tiab]) AND →

“Vegetarian diets compared to non-vegetarian diets are associated with reduced risk of total cancer and seven specific cancer types”

study authors

The evidence is a meta-analysis of seven prospective cohort studies, rated "probable" for total, colorectal, colon and breast cancer under WCRF criteria, though it remains observational.

In the brief: Large meta-analysis ties vegetarian and vegan diets to lower cancer risk across seven sites → (plant-based diet[tiab] OR vegan diet[tiab] OR vegans[tiab]) AND →